Ampicillin and sulbactam are penicillin antibiotics that fight bacteria. Pdf ampicillinsulbactam and amoxicillinclavulanate. Unasyn ampicillin sodiumsulbactam sodium dose, indications. Clinical comparative study of sulbactamampicillin and imipenemcilastatin in elderly patients with communityacquired pneumonia.
Sulbactam extends the antibacterial spectrum to proteus vulgaris, acinetobacter species and bacteroides species 1,2. Comparison of ampicillinsulbactam and imipenemcilastatin for the treatment of acinetobacter ventilatorassociated pneumonia cita. Composicion, indicaciones, presentacion y contraindicaciones. The recommended adult dose of ampicillin sulbactam is 1. In pediatric patients, the dose is based on body weight and is recommended at 300 mg per kilogram of body weight per day. Manually determine the antibiotic susceptibility of microorganisms using antimicrobial susceptibility testing ast methods in conjunction with reliable, easytouse thermo scientific oxoid ampicillin sulbactam antimicrobial susceptibility disks. The aims of this study were to develop a population pharmacokinetic pk model of ampicillin and sulbactam, to identify patient characteristics influencing the pk, and to explore the relationship between dose regimen and degree of renal impairment with exposure and time above minimum inhibitory concentration mic.
Ampicillinsulbactam is a combination of antibiotics made up of ampicillin, a betalactam and sulbactam, a betalactamase inhibitor introduced in the eighties. Ampicillin and sulbactam is a combination medicine used to treat many different types of. Dailymed ampicillin and sulbactam injection, powder, for. The adverse reactions would remain the same for the parent compound dosage. Ampicillin and sulbactam injection comes as a powder to be mixed with liquid and injected intravenously into a vein or intramuscularly into a muscle every 6 hours 4 times daily. Ampicillin sulbactam has a wide range of antibacterial activity that includes grampositive and gramnegative aerobic and anaerobic bacteria.
Ampicillin and sulbactam for injection, usp, is a sterile, injectable antibacterial combination, consisting of the semisynthelic antibiotic ampicillin sodium and the betalactamase inhibitor sulbactam sodium for intravenous and intramuscular administration. Nov 09, 2018 ampicillin and sulbactam are penicillin antibiotics that fight bacteria. To reduce the development of drugresistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection and other antibacterial drugs, ampicillin and sulbactam for injection should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. How to use ampicillin sulbactam vial with threaded port. The injectable antimicrobial combination has been marketed in over 60 countries, and prescribed for the treatment of various types of infections such as upper and lower respiratory tract infection, renal and urinary tract. Sulbactam definition of sulbactam by medical dictionary. Tal vez le muestren como usar una intravenosa en su casa. The combination could be considered particularly active against acinetobacter. Ampicillin and sulbactam is a combination medicine used to treat many different types of infections caused by bacteria.
The activities of ampicillinsulbactam and amoxicillinclavulanate were studied with 100 selected clinical escherichia coli isolates with different. Its activity against gramnegative organisms is limited. Ampicillinsulbactam side effects, dosage, interactions. Oxoid ampicillinsulbactam antimicrobial susceptibility disks. Population pharmacokinetics of ampicillin and sulbactam in. Ampicillin and sulbactam are penicillin antibiotics that fight bacteria ampicillin and sulbactam is a combination medicine used to treat many different types of infections caused by bacteria. Ampicillinsulbactam unasyn ampicillinsulbactam is a betalactambeta lactamase inhibitor combination antibiotic. Ampicillinsulbactam in elderly patients with community. Your doctor will tell you how long to use ampicillin and sulbactam injection. Manually determine the antibiotic susceptibility of microorganisms using antimicrobial susceptibility testing ast methods in conjunction with reliable, easytouse thermo scientific oxoid ampicillinsulbactam antimicrobial susceptibility disks. Ampicillin and sulbactam may also be used for purposes not listed in this medication guide.
E commercializzato in italia dallazienda welcome pharma s. However, the drug is not active against pseudomonas aeruginosa and pathogens producing extendedspectrum betalactamases. No new adverse effects are seen as a result of adding betalactamase inhibitors to betalactam antibiotics. Informate sobre efectos secundarios, dosis, precauciones y mas en medlineplus. Wood g, hanes s, boucher b y colaboradores titulo original. Ampicillinsulbactam has a wide range of antibacterial activity that includes grampositive and gramnegative aerobic and anaerobic bacteria. The first, developed in 1987 and marketed in the united states under the tradename unasyn, generic only outside the united states, is an intravenous antibiotic. Ampicillinsulbactam is a combination of the common penicillinderived antibiotic ampicillin and sulbactam, an inhibitor of bacterial betalactamase. Ampicillin 200mg, sulbactam 147mg neu foreva 4 160. Unasyn is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the betalactamase inhibitor sulbactam sodium for intravenous and intramuscular administration ampicillin sodium is derived from the penicillin nucleus, 6aminopenicillanic acid. The corresponding mean peak serum levels for sulbactam range from 48 to 88 mcgml and 21 to 40 mcgml, respectively.